研究成果
(下線：班員)
2018
Oku M, Sakai Y. Three Distinct Types of Microautophagy Based on Membrane Dynamics and
Molecular Machineries. Bioessays. [Epub ahead of print] (2018).
オートファジーフォーラムでの紹介記事
Ukai H, Araki Y, Kira S, Oikawa Y, May AI, Noda T. Gtr/Ego-independent TORC1 activation is achieved through a
glutamine-sensitive interaction with Pib2 on the vacuolar membrane. PLoS Genet. 14(4);e1007334 (2018).
オートファジーフォーラムでの紹介記事
Sato M, Sato K, Tomura K, Kosako H, Sato K. The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans. Nat Cell Biol. 20(1):81-91. (2018).
オートファジーフォーラムでの紹介記事
Sato S, Uchihara T, Fukuda T, Noda S, Kondo H, Saiki S, Komatsu M, Uchiyama Y, Tanaka K, Hattori N. Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice. Sci Rep. 8(1):2813. (2018).
オートファジーフォーラムでの紹介記事
Tatsumi T, Takayama K, Ishii S, Yamamoto A, Hara T, Minami N, Miyasaka N, Kubota T, Matsuura A, Itakura E, Tsukamoto S. Forced lipophagy reveals that lipid droplets are required for early embryonic development in mouse. Development. 145(4). (2018).
オートファジーフォーラムでの紹介記事
Kageyama S, Saito T, Obata M, Koide RH, Ichimura Y, Komatsu M. Negative regulation of the Keap1-Nrf2 pathway by a p62/Sqstm1 splicing variant. Mol Cell Biol. [Epub ahead of print] (2018).
オートファジーフォーラムでの紹介記事
2017
Yamaguchi M, Satoo K, Suzuki H, Fujioka Y, Ohsumi Y, Inagaki F, Noda NN. Atg7 Activates an Autophagy-Essential Ubiquitin-like Protein Atg8 through Multi-Step Recognition. J Mol Biol. 430(3):249-257. (2017).
オートファジーフォーラムでの紹介記事
Tamura N, Nishimura T, Sakamaki Y, Koyama-Honda I, Yamamoto H, Mizushima N. Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets. FEBS Lett. 591(23):3819-3830. (2017).
オートファジーフォーラムでの紹介記事
Kawaoka T, Ohnuki S, Ohya Y, Suzuki K. Morphometric analysis of autophagy-related structures in Saccharomyces cerevisiae. Autophagy. 13(12):2104-2110. (2017).
オートファジーフォーラムでの紹介記事
Oku M, Maeda Y, Kagohashi Y, Kondo T, Yamada M, Fujimoto T, Sakai Y. Evidence for ESCRT- and clathrin-dependent microautophagy. J Cell Biol. 216(10):3263-3274. (2017).
オートファジーフォーラムでの紹介記事
Yoshida Y, Yasuda S, Fujita T, Hamasaki M, Murakami A, Kawawaki J, Iwai K, Saeki Y, Yoshimori T, Matsuda N, Tanaka K. Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy. Proc Natl Acad Sci U S A. 114(32):8574-8579. (2017).
オートファジーフォーラムでの紹介記事
Contu VR, Hase K, Kozuka-Hata H, Oyama M, Fujiwara Y, Kabuta C, Takahashi M, Hakuno F, Takahashi SI, Wada K, Kabuta T. Lysosomal targeting of SIDT2 via multiple YxxΦ motifs is required for SIDT2 function in the process of RNautophagy. J Cell Sci. 130(17):2843-2853. (2017).
オートファジーフォーラムでの紹介記事
Hirata E, Ohya Y, Suzuki K. Atg4 plays an important role in efficient expansion of autophagic isolation membranes by cleaving lipidated Atg8 in Saccharomyces cerevisiae. PLoS One 12(7):e0181047. (2017).
オートファジーフォーラムでの紹介記事
Lu SL, Kawabata T, Cheng YL, Omori H, Hamasaki M, Kusaba T, Iwamoto R, Arimoto H, Noda T, Lin YS, Yoshimori T. Endothelial cells are intrinsically defective in xenophagy of Streptococcus pyogenes. PLoS Pathog. 13(7):e1006444. (2017).
オートファジーフォーラムでの紹介記事
Ishihara N, Maeda M, Ban T, Mihara K. Cell-free mitochondrial fusion assay detected by specific protease reaction revealed Ca2+ as regulator of mitofusin-dependent mitochondrial fusion. J Biochem. 162(4):287-294. (2017).
オートファジーフォーラムでの紹介記事
Ban T, Ishihara T, Kohno H, Saita S, Ichimura A, Maenaka K, Oka T, Mihara K, Ishihara N. Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin. Nat Cell Biol. 19(7):856-863. (2017).
オートファジーフォーラムでの紹介記事
Nishimura T, Tamura N, Kono N, Shimanaka Y, Arai H, Yamamoto H, Mizushima N. Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains. EMBO J. 36(12):1719-1735. (2017).
オートファジーフォーラムでの紹介記事
Fujimoto C, Iwasaki S, Urata S, Morishita H, Sakamaki Y, Fujioka M, Kondo K, Mizushima N, Yamasoba T. Autophagy is essential for hearing in mice. Cell Death Dis. 8(5):e2780. (2017).
オートファジーフォーラムでの紹介記事
Horie T, Kawamata T, Matsunami M, Ohsumi Y. Recycling of iron via autophagy is critical for the transition from glycolytic to respiratory growth. J Biol Chem. 292(20):8533-8543. (2017).
オートファジーフォーラムでの紹介記事
Kawamata T, Horie T, Matsunami M, Sasaki M, Ohsumi Y. Zinc starvation induces autophagy in yeast. J Biol Chem. 292(20):8520-8530. (2017).
オートファジーフォーラムでの紹介記事
Takayama K, Matsuura A, Itakura E. Dissection of ubiquitinated protein degradation by basal autophagy. FEBS Lett. 591:1199-1211. (2017).
オートファジーフォーラムでの紹介記事
Fujiwara Y, Wada K, Kabuta T. Lysosomal degradation of intracellular nucleic acids-multiple autophagic pathways. J Biochem. 161:145-154. (2017).
オートファジーフォーラムでの紹介記事
Takahashi M, Contu VR, Kabuta C, Hase K, Fujiwara Y, Wada K, Kabuta T. SIDT2 mediates gymnosis, the uptake of naked single-stranded oligonucleotides into living cells. RNA Biol. 9:1-10. (2017).
オートファジーフォーラムでの紹介記事
2016
Yamashita SI, Jin X, Furukawa K, Hamasaki M, Nezu A, Otera H, Saigusa T, Yoshimori T, Sakai Y, Mihara K, Kanki T. Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy. J Cell Biol. 215:649-665. (2016).
オートファジーフォーラムでの紹介記事
Tsuboyama K, Koyama-Honda I, Sakamaki Y, Koike M, Morishita H, Mizushima N. The ATG conjugation systems are important for degradation of the inner autophagosomal membrane. Science. 354:1036-1041. (2016).
オートファジーフォーラムでの紹介記事
Aizawa S, Contu VR, Fujiwara Y, Hase K, Kikuchi H, Kabuta C, Wada K, Kabuta T. Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes. Autophagy. 13:218-222. (2016).
オートファジーフォーラムでの紹介記事
Kaizuka T, Morishita H, Hama Y, Tsukamoto S, Matsui T, Toyota Y, Kodama A, Ishihara T, Mizushima T, Mizushima N. An Autophagic Flux Probe that Releases an Internal Control. Mol Cell. 64:835-849. (2016).
オートファジーフォーラムでの紹介記事
Imai K, Hao F, Fujita N, Tsuji Y, Oe Y, Araki Y, Hamasaki M, Noda T, Yoshimori T. Atg9A trafficking through the recycling endosomes is required for autophagosome formation. J Cell Sci. 129:3781-3791. (2016).
オートファジーフォーラムでの紹介記事
Tanaka S, Hikita H, Tatsumi T, Sakamori R, Nozaki Y, Sakane S, Shiode Y, Nakabori T, Saito Y, Hiramatsu N, Tabata K, Kawabata T, Hamasaki M, Eguchi H, Nagano H, Yoshimori T, Takehara T. Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice. Hepatology. 64:1994-2014. (2016).
オートファジーフォーラムでの紹介記事
Yoshii SR, Kuma A, Akashi T, Hara T, Yamamoto A, Kurikawa Y, Itakura E, Tsukamoto S, Shitara H, Eishi Y, Mizushima N. Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons. Dev Cell. 39:116-130. (2016).
オートファジーフォーラムでの紹介記事
Muona M, Ishimura R, Laari A, Ichimura Y, Linnankivi T, Keski-Filppula R, Herva R, Rantala H, Paetau A, Pöyhönen M, Obata M, Uemura T, Karhu T, Bizen N, Takebayashi H, McKee S, Parker MJ, Akawi N, McRae J, Hurles ME; DDD Study, Kuismin O, Kurki MI, Anttonen AK, Tanaka K, Palotie A, Waguri S, Lehesjoki AE, Komatsu M. Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy. Am J Hum Genet. 99:683-94.(2016).
オートファジーフォーラムでの紹介記事
Yamamoto H, Fujioka Y, Suzuki SW, Noshiro D, Suzuki H, Kondo-Kakuta C, Kimura Y, Hirano H, Ando T, Noda NN, Ohsumi Y. The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes. Dev Cell. 38:86-99.(2016).
オートファジーフォーラムでの紹介記事
Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, Ohishi M, Endo K, Uemura T, Nishito Y, Okuda S, Obata M, Kouno T, Imamura R, Tada Y, Obata R, Yasuda D, Takahashi K, Fujimura T, Pi J, Lee MS, Ueno T, Ohe T, Mashino T, Wakai T, Kojima H, Okabe T, Nagano T, Motohashi H, Waguri S, Soga T, Yamamoto M, Tanaka K, Komatsu M. p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming. Nat Commun. 7:12030(2016).
オートファジーフォーラムでの紹介記事
Hasegawa J, Iwamoto R, Otomo T, Nezu A, Hamasaki M, Yoshimori T. Autophagosome-lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome. EMBO J. 35:1853-67.(2016).
オートファジーフォーラムでの紹介記事
Yamasaki A, Watanabe Y, Adachi W, Suzuki K, Matoba K, Kirisako H, Kumeta H, Nakatogawa H, Ohsumi Y, Inagaki F, Noda NN. Structural Basis for Receptor-Mediated Selective Autophagy of Aminopeptidase I Aggregates. Cell Rep. 16:19-27.(2016).
オートファジーフォーラムでの紹介記事
Habisov S, Huber J, Ichimura Y, Akutsu M, Rogova N, Loehr F, McEwan DG, Johansen T, Dikic I, Doetsch V, Komatsu M, Rogov VV, Kirkin V. Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation. J Biol Chem. 291:9025-41.(2016).
オートファジーフォーラムでの紹介記事
Hirano S, Uemura T, Annoh H, Fujita N, Waguri S, Itoh T, Fukuda M. Differing susceptibility to autophagic degradation of two LC3-binding proteins: SQSTM1/p62 and TBC1D25/OATL1. Autophagy. 12:312-26(2016).
オートファジーフォーラムでの紹介記事
Aizawa S, Fujiwara Y, Contu VR, Hase K, Takahashi M, Kikuchi H, Kabuta C, Wada K, Kabuta T. Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes. Autophagy. 12:565-78(2016).
オートファジーフォーラムでの紹介記事
Yamamoto-Nonaka K, Koike M, Asanuma K, Takagi M, Oliva Trejo JA, Seki T, Hidaka T, Ichimura K, Sakai T, Tada N, Ueno T, Uchiyama Y, Tomino Y. Cathepsin D in podocytes is important in the pathogenesis of proteinuria and CKD. J. Am. Soc. Nephrol. [Epub ahead of print]
オートファジーフォーラムでの紹介記事
Kira S, Kumano Y, Ukai H, Takeda E, Matsuura A, Noda T. Dynamic relocation of the TORC1-Gtr1/2-Ego1/2/3 complex is regulated by Gtr1 and Gtr2. Mol. Biol. Cell27: 382-396 (2016).
オートファジーフォーラムでの紹介記事
2015
Mehanna S, Suzuki C, Shibata M, Sunabori T, Imanaka T, Araki K, Yamamura KI, Uchiyama Y, Ohmuraya M. Cathepsin D in pancreatic acinar cells is implicated in cathepsin B and L degradation, but not in autophagic activity. Biochem. Biophys Res. Commun. 469: 405-411 (2015).
オートファジーフォーラムでの紹介記事
Wu F, Watanabe Y, Guo XY, Qi X, Wang P, Zhao HY, Wang Z, Fujioka Y, Zhang H, Ren JQ, Fang TC, Shen YX, Feng W, Hu JJ, Noda NN, Zhang H. Structural basis of the differential function of the two C. elegans Atg8 homologs, LGG-1 and LGG-2, in autophagy. Mol. Cell 60: 914-929 (2015).
オートファジーフォーラムでの紹介記事
Arasaki K, Shimizu H, Mogari H, Nishida N, Hirota N, Furuno A, Kudo Y, Baba M, Baba N, Cheng J, Fujimoto T, Ishihara N, Ortiz-Sandoval C, Barlow LD, Raturi A, Dohmae N, Wakana Y, Inoue H, Tani K, Dacks JB, Simmen T, Tagaya M. A role for the ancient SNARE syntaxin 17 in regulating mitochondrial division. Dev. Cell 32: 304-317 (2015).
オートファジーフォーラムでの紹介記事
Eino A, Kageyama S, Uemura T, Annoh H, Saito T, Narita I, Waguri S, Komatsu M. Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells. J. Cell Sci. 128: 4453-4461 (2015).
オートファジーフォーラムでの紹介記事
Hieke N, Löffler AS, Kaizuka T, Berleth N, Böhler P, Drießen S, Stuhldreier F, Friesen O, Assani K, Schmitz K, Peter C, Diedrich B, Dengjel J, Holland P, Simonsen A, Wesselborg S, Mizushima N, Stork B. Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells. Autophagy. 11: 1471-1483 (2015).
オートファジーフォーラムでの紹介記事
Kaizuka T, Mizushima N. Atg13 is essential for autophagy and cardiac development in mice. Mol. Cell Biol. 36: 585-595 (2015).
オートファジーフォーラムでの紹介記事
Yamamoto H, Shima T, Yamaguchi M, Mochizuki Y, Hoshida H, Kakuta S, Kondo-Kakuta, Noda NN, Inagaki F, Itoh T, Akada R, Ohsumi Y. The thermotolerant yeast Kluyveromyces marxianus is a useful organism for structural and biochemical studies of autophagy. J. Biol. Chem. 290: 29506-29518 (2015).
オートファジーフォーラムでの紹介記事
Sakakibara K, Eiyama A, Suzuki SW, Sakoh-Nakatogawa M, Okumura N, Tani M, Hashimoto A, Nagumo S, Kondo-Okamoto N, Kondo-Kakuta C, Asai E, Kirisako H, Nakatogawa H, Kuge O, Takao T, Ohsumi Y, Okamoto K. Phospholipid methylation controls Atg32-mediated mitophagy and Atg8 recycling. EMBO J. 34: 2703-2719 (2015).
オートファジーフォーラムでの紹介記事
Eiyama A, Okamoto K. Protein N-terminal acetylation by NatA is critical for selective mitochondria degradation. J. Biol. Chem. 290: 25034-25044 (2015).
オートファジーフォーラムでの紹介記事
Hase K, Fujiwara Y, Kikuchi H, Aizawa S, Hakuno F, Takahashi S, Wada K, Kabuta T. RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates. Nucleic Acids Res. 43: 6439-6449 (2015).
オートファジーフォーラムでの紹介記事
Murakawa T, Yamaguchi O, Hashimoto A, Hikoso S, Takeda T, Oka T, Yasui H, Ueda H, Akazawa Y, Nakayama H, Taneike M, Misaka T, Omiya S, Shah AM, Yamamoto A, Nishida K, Ohsumi Y, Okamoto K, Sakata Y, Otsu K. Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation. Nat. Commun. 6: 7527 (2015).
オートファジーフォーラムでの紹介記事
Maeda Y, Oku M, Sakai Y. A defect of the vacuolar putative lipase Atg15 accelerates degradation of lipid droplets through lipolysis. Autophagy 11: 1247-1258 (2015).
オートファジーフォーラムでの紹介記事
Suzuki H, Kaizuka T, Mizushima N, Noda NN. Structure of the Atg101-Atg13 complex reveals essential roles of Atg101 in autophagy initiation. Nat. Struct. Mol. Biol. 22: 572-580 (2015).
オートファジーフォーラムでの紹介記事
Mochida K, Oikawa Y, Kimura Y, Kirisako H, Hirano H, Ohsumi Y, Nakatogawa H. Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus. Nature 522: 359-362 (2015).
オートファジーフォーラムでの紹介記事
Noda NN, Fujioka Y. Atg1 family kinases in autophagy initiation. Cell. Mol. Life Sci.72: 3083-96 (2015).
オートファジーフォーラムでの紹介記事
Picazarri K, Nakada-Tsukui K, Tsuboi K, Miyamoto E, Watanabe N, Kawakami E, Nozaki T. Atg8 is involved in endosomal and phagosomal acidification in the parasitic protist Entamoeba histolytica. Cell. Microbiol. doi: 10.1111/cmi.12453 (2015).
オートファジーフォーラムでの紹介記事
Shiraishi K, Oku M, Kawaguchi K, Uchida D, Yurimoto H, Sakai Y. Yeast nitrogen utilization in the phyllosphere during plant lifespan under regulation of autophagy. Sci. Rep. 5: 9719 (2015).
オートファジーフォーラムでの紹介記事
Fujiwara Y, Hase K, Wada K, Kabuta T. An RNautophagy/DNautophagy receptor, LAMP2C, possesses an arginine-rich motif that mediates RNA/DNA-binding. Biochem. Biophys. Res. Commun. 460: 281-286 (2015).
オートファジーフォーラムでの紹介記事
Noda NN, Inagaki F. Mechanisms of Autophagy. Annu. Rev. Biophys. E44: 101-122 (2015).
オートファジーフォーラムでの紹介記事
Nishioka K, Oyama G, Yoshino H, Li Y, Matsushima T, Takeuchi C, Mochizuki Y, Mori-Yoshimura M, Murata M, Yamasita C, Nakamura N, Konishi Y, Ohi K, Ichikawa K, Terada T, Obi T, Funayama M, Saiki S, Hattori N. High frequency of beta-propeller protein-associated neurodegeneration (BPAN) among patients with intellectual disability and young-onset parkinsonism. Neurobiol. Aging 36: 2004.e9-2004.e15 (2015).
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Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, Li Y, Ogaki K, Ando M, Yoshino H, Tomiyama H, Nishioka K, Hasegawa K, Saiki H, Satake W, Mogushi K, Sasaki R, Kokubo Y, Kuzuhara S, Toda T, Mizuno Y, Uchiyama Y, Ohno K, Hattori N. CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study. Lancet Neurol. 14: 274-282 (2015).
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Suzuki SW, Yamamoto H, Oikawa Y, Kondo-Kakuta C, Kimura Y, Hirano H, Ohsumi Y. Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation. Proc. Natl. Acad. Sci. USA 112: 3350-3355 (2015).
オートファジーフォーラムでの紹介記事
Sakoh-Nakatogawa M, Kirisako H, Nakatogawa H, Ohsumi Y. Localization of Atg3 to autophagy-related membranes and its enhancement by the Atg8-family interacting motif to promote expansion of the membranes. FEBS Lett. 589: 744-749 (2015).
オートファジーフォーラムでの紹介記事
Ngu MP, Hirata E, Suzuki K. Visualization of Atg3 during Autophagosome Formation in Saccharomyces cerevisiae. J. Biol. Chem. 290: 8146-8153. (2015).
オートファジーフォーラムでの紹介記事
2014
Mochida K, Ohsumi Y, Nakatogawa H. Hrr25 phosphorylates the autophagic receptor Atg34 to promote vacuolar transport of α-mannosidase under nitrogen starvation conditions. FEBS Lett. 588: 3862-3869 (2014).
オートファジーフォーラムでの紹介記事
Tanaka C, Tan LJ, Mochida K, Kirisako H, Koizumi M, Asai E, Sakoh-Nakatogawa M, Ohsumi Y, Nakatogawa H. Hrr25 triggers selective autophagy-related pathways by phosphorylating receptor proteins. J. Cell Biol. 207: 91-105 (2014).
オートファジーフォーラムでの紹介記事
Shigihara N, Fukunaka A, Hara A, Komiya K, Honda A, Uchida T, Abe H, Toyofuku Y, Tamaki M, Ogihara T, Miyatsuka T, Hiddinga HJ, Sakagashira S, Koike M, Uchiyama Y, Yoshimori T, Eberhardt NL, Fujitani Y, Watada H. Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy. J. Clin. Invest. 124: 3634-3644 (2014).
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Ogasawara Y, Itakura E, Kono N, Mizushima N, Arai H, Nara A, Mizukami T, Yamamoto A. Stearoyl-CoA desaturase 1 activity is required for autophagosome formation. J. Biol. Chem. 289: 23938-23950.
オートファジーフォーラムでの紹介記事
Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, Komatsu M. Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway. J. Biol. Chem. 289: 24944-24955.
オートファジーフォーラムでの紹介記事
Kishi-Itakura C, Koyama-Honda I, Itakura E, Mizushima N. Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells. J. Cell Sci. 127: 4089-4102.
オートファジーフォーラムでの紹介記事
Kira S, Tabata K, Shirahama-Noda K, Nozoe A, Yoshimori T, Noda T. Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy. Autophagy 10: 1565-1578.
オートファジーフォーラムでの紹介記事
Fujioka Y, Suzuki SW, Yamamoto H, Kondo-Kakuta C, Kimura Y, Hirano H, Akada R, Inagaki F, Ohsumi Y, Noda NN. Structural basis of starvation-induced assembly of the autophagy initiation complex. Nat. Struct. Mol. Biol. 21: 513-521 (2014).
オートファジーフォーラムでの紹介記事
Matsui T, Noguchi K, Fukuda M Dennd3 Functions as a guanine nucleotide exchange factor for small GTPase Rab12 in mouse embryonic fibroblasts. J. Biol. Chem. 289: 13986-13995 (2014).
オートファジーフォーラムでの紹介記事
Lystad AH, Ichimura Y, Takagi K, Yang Y, Pankiv S, Kanegae Y, Kageyama S, Suzuki M, Saito I, Mizushima T, Komatsu M, Simonsen A. Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures. EMBO Rep. 15: 557-565 (2014).
オートファジーフォーラムでの紹介記事
Ishimura R, Tanaka K, Komatsu M. Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy. FEBS Lett. 588: 822-828 (2014).
オートファジーフォーラムでの紹介記事
Uemura T, Yamamoto M, Kametaka A, Sou YS, Yabashi A, Yamada A, Annoh H, Kametaka S, Komatsu M, Waguri S. A cluster of thin tubular structures mediates transformation of the ER to autophagic isolation membrane. Mol. Cell Biol. 34: 1695-1706 (2014).
オートファジーフォーラムでの紹介記事
Tsukamoto S, Hara T, Yamamoto A, Kito S, Minami N, Kubota T, Sato K, Kokubo T. Fluorescence-based visualization of autophagic activity predicts mouse embryo viability. Sci. Rep. 4: 4533 (2014).
オートファジーフォーラムでの紹介記事
Sahani MH, Itakura E, Mizushima N. Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids. Autophagy 10: 431-441 (2014).
オートファジーフォーラムでの紹介記事
Jiang P, Nishimura T, Sakamaki Y, Itakura E, Hatta T, Natsume T, Mizushima N. The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17. Mol. Biol. Cell 25: 1327-1337 (2014).
オートファジーフォーラムでの紹介記事
2013
Maejima I, Takahashi A, Omori H, Kimura T, Takabatake Y, Saitoh T, Yamamoto A, Hamasaki M, Noda T, Isaka Y, Yoshimori T. Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury. EMBO J. 32: 2336-2347 (2013).
オートファジーフォーラムでの紹介記事
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